ea0029oc9.5 | Endocrine Tumours & Translation | ICEECE2012
Christ E.
, Forrer F.
, Wild D.
, Clerici T.
, Braendle M.
, Maecke H.
, Ell P.
, Caplin M.
, Gloor B.
, Reubi J.
Background: Although biochemical diagnosis of endogenous hyperinsulinemic hypoglycemia is straightforward, surgical removal of an insulinoma is hampered by difficulties to localize it using conventional radiological procedures (endosonography, MRI, CT-imaging techniques).In vitro data suggest that human insulinoma cells exhibit a high density of GLP-1R. 111In-exendin-4 is a 111In labeled GLP-1R agonist that binds with high affinity to GLP-1R and m...